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Search Results for " il-23 receptor "

Targets Recommended: Prostaglandin Receptor

3

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T28958	TG6-129 TG6 129	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TG6-129 是有效的EP2受体选择性拮抗剂，可降低 butaprost 诱导的 P388D1 巨噬细胞中炎症因子的表达。
T14687	Deucravacitinib BMS-986165	Tyrosine Kinases; JAK; IFNAR; Interleukin	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂，用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活，可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域，IC50为1.0 nM。
T6404	Bazedoxifene hydrochloride Bazedoxifene HCl,盐酸巴多昔芬,TSE-424	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Bazedoxifene hydrochloride (TSE-424) 是一种 IL-6/GP130蛋白相互作用抑制剂，可用于胰腺癌的研究。它也是一种有口服活性的，能透过血脑屏障的，非甾体、选择性的雌激素受体调节剂 (SERM)，对 ERα 和 ERβ 作用的 IC50值分别为 26 nM 和 99 nM，可用于研究骨质疏松症。

化合物

Cat.No: T28958

Synonym: TG6 129

Target: Prostaglandin Receptor

Deucravacitinib

Cat.No: T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

Bazedoxifene hydrochloride

Cat.No: T6404

Synonym: Bazedoxifene HCl,盐酸巴多昔芬,TSE-424

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat. No.	Product Name	Target	Signaling Pathways
TN6722	Terminolic acid 2α,6β,23-trihydroxyl oleanolic acid	Antibacterial	Microbiology/Virology
	Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) 是一种从 Combretum racemosum 中分离得到的五环三萜糖苷，可通过与 IL-1β 和 IL-6 的受体活性位点结合抑制促炎细胞因子，并通过与 IL-4 受体结合位点结合增强抗炎细胞因子。它还表现出适度的抗菌活性。

天然产物

Terminolic acid

Cat.No: TN6722

Synonym: 2α,6β,23-trihydroxyl oleanolic acid

Target: Antibacterial

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00575	IL-23R Protein, Canine, Recombinant (His) IBD17,IL-23 R,IL-23 ...	Canine	HEK293 Cells
	IL-23R Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.31 kDa and the accession number is A0A8I3PXL0.
TMPJ-01219	IL-23R Protein, Mouse, Recombinant (hFc) Il23r,IL-23R,interleukin...	Mouse	HEK293 Cells
	Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, an...
TMPJ-00351	IL-23R Protein, Human, Recombinant (aa 24-353, hFc) IL-23 receptor,IL23<...	Human	HEK293 Cells
	Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the I...
TMPK-00353	IL-23R Protein, Human, Recombinant (aa 24-355, His) IL-23 R,IBD17,IL-23 ...	Human	HEK293 Cells
	IL-23R Protein, Human, Recombinant (aa 24-355, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.15 kDa and the accession number is Q5VWK5-1.
TMPK-01094	IL-23R Protein, Mouse, Recombinant (His) IL-23 receptor,Il23<...	Mouse	HEK293 Cells
	IL-23R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 41.48 kDa and the accession number is Q8K4B4.
TMPK-00652	IL-23R Protein, Cynomolgus, Recombinant (His) IL-23 R,IL-23 recept...	Cynomolgus	HEK293 Cells
	IL-23R Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.03 kDa and the accession number is G7NWY5.
TMPH-00779	IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)	Guinea pig	E. coli
	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible fo...
TMPK-01378	IL-12B Protein, Cynomolgus, Recombinant (His) CLMF2,NKSF2,CLMF,CLMF p40,IL-12B,IL-12 sub...	Cynomolgus	HEK293 Cells
	Interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3.Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studi...
TMPJ-00047	IL-31 Protein, Human, Recombinant IL-31,Interleukin-31,白介素,白细胞介素,IL31	Human	E. coli
	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper...

重组蛋白

IL-23R Protein, Canine, Recombinant (His)

Cat.No: TMPK-00575

Species: Canine

Expression System: HEK293 Cells

IL-23R Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01219

Species: Mouse

Expression System: HEK293 Cells

IL-23R Protein, Human, Recombinant (aa 24-353, hFc)

Cat.No: TMPJ-00351

Species: Human

Expression System: HEK293 Cells

IL-23R Protein, Human, Recombinant (aa 24-355, His)

Cat.No: TMPK-00353

Species: Human

Expression System: HEK293 Cells

IL-23R Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01094

Species: Mouse

Expression System: HEK293 Cells

IL-23R Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00652

Species: Cynomolgus

Expression System: HEK293 Cells

IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)

Cat.No: TMPH-00779

Species: Guinea pig

Expression System: E. coli

IL-12B Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01378

Species: Cynomolgus

Expression System: HEK293 Cells

IL-31 Protein, Human, Recombinant

Cat.No: TMPJ-00047

Species: Human

Expression System: E. coli

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